Description
Introduction: Malarial remains a great public health concern, especially in developing countries, largely because of parasite resistance to the majority of the currently available treatment options. On this basis, the ethyl acetate fraction of Commiphora pedunculata, a medicinal plant with reported antioxidant and anti-inflammatory properties, was investigated for its therapeutic effect on Plasmodium berghei together with anaemia and oxidative organ damage triggered by P. berghei.
Methodology: Mice were infected with chloroquine-sensitive strain of P. berghei and orally treated with ethyl acetate fraction of C. pedunculata at doses of 50 and 100 mg/kg body weight (BW) for seven days. The parasitemia, packed cell volume as well as redox sensitive biomarkers (thiobarbituric acid reactive substances level, reduced glutathione concentration, superoxide dismutase activity and catalase activity) in the spleen, brain and liver were estimated.
Results and Discussions: Our result revealed that ethyl acetate fraction of C. pedunculata significantly (p < 0.05) repressed P. berghei multiplication in a non-dose-dependent fashion. Additionally, the fraction significantly (p < 0.05) mitigated the P. berghei-induced anaemia at both doses and oxidative organ damage at a dose of 50 mg/kg BW.
Conclusions: Put together, this study evidently indicated that ethyl acetate fraction of C. pedunculata has antiplasmodial potential and ameliorative role towards pathological alterations caused by P. berghei.
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