Description
Abstract
Background: Staphylococcus aureus (MRSA) one common human pathogen that causes infections nosocomial infections. Existed data on MRSA colonization among hemodialysis patients in sub-Saharan Africa including Ethiopia are limited. Thus, we determined the heft of MRSA colonization in among hemodialysis patients in St. Paulo's Hospital Millennium Medical College, Zewditu Memorial Hospital, and Minillik II referral Hospital dialysis centre Addis Ababa, Ethiopia.
Method: Using a multi-center cross-sectional study. Hemodialysis patients (HDP) were screened for MRSA colonization between 2021 to August 2021 using nasal nares swab. the swabs were process using standard microbiological techniques including antimicrobial resistance mecA gene. In order to evaluate the risk variables associated to MRSA colonization in dialysis patients, Sociodemographic data were collected through the use of an structured questionnaires.
Result: A total of 111 hemodialysis patients screened for S. aureus carriage and Methicillin Resistance Staphylococcus aureus colonization. We identified that 43.2% and 27.9% of S. aureus carriers and MRSA colonization in acute and chronic hemodialysis patients. Inpatient (OR 4.342, 95% CL 1.542, 12.330) (p=0.006) were dominantly colonized by MRSA. Risk factor factors including SARS-CoV-2 (severe acute respiratory syndrome-corona virus) (p=0.04) and Antibiotic intake (OR 3.5583 95% CL 1.625, 7.89) (p=0.002) were also significantly associated for the carriage of S. aureus. Diabetics (OR 2.882, 95% CL 1.442, 7.258) (p=0.025) and inpatient (OR 4.342,95% CL 1.542, 12.330) (P=0.005) risk factor were strongly associated with MRSA colonization. On our investigation, 12.9% were Vancomycin intermediate Staphylococcus aureus. The majority S. aureus isolates were highly resistant to penicillin (97.7%) and erythromycin (60.4%), with 6.3% of the isolates being A multi-drug resistance resistant.
Conclusion: this presented study is the first report in Ethiopia on MRSA colonization in hemodialysis patients using mecA and demonstrated that MRSA carriage rates in HDPs are generally similar to data made in a few other countries and that MRSA carriage burdens are higher in HDP hospitalized patients. In order to improve intervention strategies, our data support the systematic screening of MRSA during admission, transit from another hospital and antimicrobial stewardship.
Keywords: - Dialysis, Colonization, maintenance dialysis, Nares, methicillin-resistant staphylococcus aureus, and Vancomycin resistance staphylococcus aureus.
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